Published: November 1, 2018 4:56:21 pm
A low-fat diet may help increase the cancer survival charge of overweight youngsters with acute lymphoblastic leukemia, the most typical childhood cancer, a research claims. Researchers from the University of California, Los Angeles (UCLA) in the US administered the chemotherapy drug vincristine to overweight and non-obese mice with leukemia.
They found that in the event that they switched the overweight mice from a high-fat to a low-fat diet instantly earlier than beginning chemotherapy, the mice had a dramatically improved end result. The mice on the low-fat diet had a 5 instances increased survival charge than the mice in the high-fat diet group, the research revealed in the journal Cancer & Metabolism discovered.
“The most exciting thing to me about this study is the fact that this shows that a dietary intervention could potentially help us kill leukemia cells in children with acute lymphoblastic leukemia,” stated Steven Mittelman from UCLA Mattel Children’s Hospital. “The current treatments for leukemia are very toxic, so finding a way to use a healthy diet, without increasing the toxicity of therapy to treat people with cancer, would be incredible,” Mittelman stated. This analysis builds on previous work by Mittelman that discovered that weight problems made chemotherapy medicine a lot much less efficient in youngsters with leukemia.
After chemotherapy, overweight youngsters with leukemia relapse 50 p.c extra typically than their lean counterparts.
Recent research have additionally discovered that one in three youngsters with acute lymphoblastic leukemia was chubby or overweight at prognosis. Acute lymphoblastic leukemia is a cancer of the lymphoid line of blood cells characterised by the event of enormous numbers of immature lymphocytes.
“During past research, the question that always came up was, is this something you can reverse and should we be putting our kids on a diet? So we decided to test that in the mice,” Mittelman stated. The mice that had been switched to a low-fat diet had a dramatically improved survival charge of 92 p.c, whereas the mice on the high-fat diet had a 17 p.c survival charge, researchers stated.
“There are very few things in life you can do for one month that may have such a tremendous potential benefit, especially for your child who has cancer,” stated Jonathan Tucci from the University of Southern California. The analysis group has begun to maneuver its analysis to human trials at Children’s Hospital Los Angeles. The group has began a pilot research that exams the flexibility of a targeted diet and exercise intervention to cut back fats achieve throughout chemotherapy for childhood acute lymphoblastic leukemia and to doubtlessly enhance survival charges.